Build and Runes
His ult can be used while he’s moving, so watch out as he may try to kite you.
His damaging skills have long range and are mostly skill shots, so awareness and good dodging skills are important.
Watch out for his Q in lane as it can pass through minions for a longer range, try to stay to the side of the minions.
Attempt to stay on the same side of the creep wave as Lucian, e.g if he stands to the left, stand to the left. This will give him a much harder time with harassing you using Piercing Light.
Buying a Frozen Heart will reduce the amount of shots from the Culling (if you are nearby), thus reducing the amount of damage dealt.