Avoid letting her harass you for free, as it will lower her Mantra’s cooldown.
Try your best to escape from her Focused Resolve when she casts it on you, as it will root you after a short while.
Leave the circle from her Mantra Inner Flame as it will deal bonus damage in the circle after a short duration.
Most effective poke for Karma is her Q. Esp. when she has Inner Flame on. I personally only use that to poke to save mana. Bait that poke early game before you dive. It does serious dmg and can slow you for lots of AA cooldown.