Build and Runes
Stay behind minions so that she won’t be able to stun you.
When at low health, Play very defensively as her Spider form’s Bite deals more damage the lower your health is.
Try to read where the Elise will land after she uses Rappel – she can’t go anywhere if there are no minions/targets to jump to.
If Elise uses Rappel to enter a teamfight, focus her – Rappel is Elise’s only escape ability.