Builds and Runes
After level 6, try to prevent her use of Mark of the Assassin, as she can proc it twice using her dashes.
Akali will still be hit by AOE abilities while inside her shroud.
Try to carry a pink ward against her so that she can’t use her shroud defensively.
Picking a stealth reveal champion such as Lee Sin, will make things much harder for Akali as she will not be able to her shroud as freely.
Akali is best at level 6, punish her in lane as much as you can before she can get her ultimate.
Unlike other ap champs, Akali doesn’t get her full dmg output as soon as she hits lvl 6. She only gets 1 single charge of her ult. Don’t wait for her to get the 2 others to attack, and show her your lvl 6 is better.
Buy and upgrade the oracles lens, it will negate the stealth she gains from her shroud and it will prevent you from having to waste pink wards every time you fight her.
Akali will win most melee trades, stay in safe range or lock her down. Snares work good, pick champions like Morgana, Ryze. Syndra is also great at keeping Akali away.
Pick a champion that can take a beating. Akali is practically MADE to kill squishies.